Endocrine Abstracts

Background: Multiple endocrine neoplasms (MEN) are a rare hereditary syndrome, caused by an autosomal dominant mutation due to germline mutation in the rearranged during transfection (RET) proto-oncogene. According to the new WHO guidelines, MEN type 2 (formerly known as MEN 2A) is characterised by medullary thyroid cancer (MTC), paragangliomas, primary hyperparathyroidism (PHP) and cutaneous lichen amyloidosis.Objectives: To present the clinical and par...

Introduction: Neuroendocrine neoplasms are rare heterogeneous malignancies originating from neuroendocrine cells throughout the body. The most common primary sites are the gastrointestinal and respiratory tracts, but can originate from almost any organ, some in unusual locations. The diagnosis is based on the confirmation of the endocrine nature of the tumor and secondly the confirmation of its primary nature. We describe two cases with a very rare primary localization of neur...

Pituitary apoplexy, a rare but impactful complication of pituitary adenomas, involves sudden hemorrhage or infarction within the pituitary gland, leading to diverse clinical presentations and complications, ranging from severe headaches to panhypopituitarism. This case series explores the intersection of pituitary apoplexy and the subsequent cessation of tumor secretion in five patients with various secreting pituitary adenomas, offering unique insights into potential curative...

Background: Normal sex development is warranted by a complex and coordinated interaction between mutually antagonistic activating and repressing genetic and hormonal factors that act in a strict spatio-temporal sequence. Deviations from this established pattern can result in heterogenous chromosomal, gonadal or phenotypic congenital abnormalities named disorders of sexual development (DSD). We present a rare case of early testicular regression syndrome.C...

Introduction: Medullary thyroid carcinoma (MTC) is defined as a rare neuroendocrine tumor originated from the parafollicular C cells of the thyroid, noted for the ability of secreting calcitonin and other peptides. MTC poses a high risk of mortality if left untreated as the tumoral cells can invade nearby tissues, lymph nodes, lymphatic or blood vessels and, ultimately, other organs. Calcitonin is key in the evaluation and treatment protocol as its basal serum levels tend to b...

Background: Subacute thyroiditis, autoimmune thyroiditis and an atypical form of thyroiditis due to primary injury of the thyroid gland by SARS Cov2 itself are complications of COVID-19. Angiotensin-converting enzyme 2 is also expressed in the thyroid gland. On the other hand, both untreated thyrotoxicosis and COVID-19 affects heart, generating cardiac complications.Case report: A 36-year-old woman resident in an iodine sufficient area, heavy smoker, pre...

Introduction: McCune-Albright syndrome is a rare, heterogenous disorder, consisting of at least two of the following three features: polyostotic fibrous dysplasia, café-au-lait skin pigmentation and autonomous endocrine hyperfunction. We present the case of a patient with an atypical presentation of McCune Albright syndrome (MAS) and severe fibrous dysplasia lesions.Case report: An 18-year-old girl diagnosed with MAS (at the age of four) was referre...

Context: The current pandemic showed a great handling of the resources and research in order to find not only a way to cure but also to prevent and improve the course of the Covid-19 infection. Optimal vitamin D (VD) levels and treatment was seen as a potential aid due, in principal, to its immunomodulatory effect. The ACE-2 receptor is the key the virus uses for entering the body, but its location is not restricted to the lungs, it’s also found in the adrenal cortex. At ...

Introduction: Acromegaly is a rare, chronic endocrinopathy, that results from persistent hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor 1 (IGF1). It is well known that GH excess has multisystemic effects throughout the body, but its interaction with the immune system has only been suggested in the last few decades. This prompted us to explore the frequency of autoimmune disorders in a retrospective acromegaly cohort....

Background: Dopamine agonists (DAs) were associated with valvular dysfunction in patients with Parkinson’s disease due to their fibrotic effect through the serotoninergic receptor. It is more difficult to prove the same effects in patients with prolactinoma due to the lower doses, variable doses and the longer follow-up period. Aim: To assess echocardiographic features in patients with prolactinoma under DA treatment.Methods: ...